Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

The endoplasmic reticulum (ER), mitochondria and lysosomes are physically and/or
functionally linked, establishing close contact sites between these organelles. As a …

Ca2+ mobilization from intracellular stores represents an important cell signalling process
that is regulated, in mammalian cells, by inositol-1, 4, 5-trisphosphate (InsP3), cyclic ADP …

Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …

Since the beginning of the last century, seminal discoveries have identified pyridine
nucleotides as the major redox carriers in all organisms. Recent research has unravelled an …

Potassium is the most abundant ion to face both plasma and organelle membranes.
Extensive research over the past seven decades has characterized how K+ permeates the …

Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes Ca 2+ in many cells and
species. Unlike other Ca 2+-mobilizing messengers, NAADP mobilizes Ca 2+ from an …

Accumulating evidence implicates acidic organelles of the endolysosomal system as
mobilisable stores of Ca2+ but their relationship to the better-characterised endoplasmic …

Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate were discovered> 2
decades ago. That they are second messengers for mobilizing Ca 2+ stores has since been …