TMEM16A in smooth muscle cells acts as a pacemaker channel in the internal anal sphincter

P Lu, LM Lifshitz, K Bellve, R ZhuGe - Communications Biology, 2024 - nature.com
Maintenance of fecal continence requires a continuous or basal tone of the internal anal
sphincter (IAS). Paradoxically, the basal tone results largely from high-frequency rhythmic …

Mode Switch of Ca2 + Oscillation-Mediated Uterine Peristalsis and Associated Embryo Implantation Impairments in Mouse Adenomyosis

M Qu, P Lu, K Bellve, LM Lifshitz, R ZhuGe - Frontiers in Physiology, 2021 - frontiersin.org
Adenomyosis is a debilitating gynecological disease of the uterus with no medicinal cure.
The tissue injury and repair hypothesis for adenomyosis suggests that uterine …

[HTML][HTML] A systematic review of translation and experimental studies on internal anal sphincter for fecal incontinence

M Kim, BY Oh, JS Lee, D Yoon, W Chun… - Annals of …, 2022 - ncbi.nlm.nih.gov
The complexity in the molecular mechanism of the internal anal sphincter (IAS) limits
preclinical or clinical outcomes of fecal incontinence (FI) treatment. So far, there are no …

3D spheroids versus 2D-cultured human adipose stem cells to generate smooth muscle cells in an internal anal sphincter-targeting cryoinjured mouse model

I Son, M Kim, JS Lee, D Yoon, YR Kim, JH Park… - Stem Cell Research & …, 2024 - Springer
Background The efficacy of cell implantation via 3D-spheroids to treat basal tone in fecal
incontinence remains unclear. To address this, in this study, we aimed to identify cell …

[HTML][HTML] 孕酮通过RhoA/ROCK 信号通路促进子宫平滑肌收缩的机制研究

严小丽, 陈诚, 王丹, 常青 - 2022 - aammt.tmmu.edu.cn
目的探讨孕酮通过RhoA/ROCK 信号通路影响子宫平滑肌收缩的作用机制.
方法收集临产与未临产人子宫平滑肌组织各5 例, 采用Western blot 和免疫组化检测肌球蛋白轻 …

[HTML][HTML] Revisión de la fisiología anorrectal y posibles compuestos bioactivos para la erocosmética

S Monge Jiménez, M Piedra Robles… - … de Ciencias Químico …, 2022 - scielo.org.co
MONGE JIMENEZ, Sebastián et al. Revisión de la fisiología anorrectal y posibles
compuestos bioactivos para la erocosmética. Rev. colomb. cienc. quim. farm.[online]. 2022 …