Homology modeling in drug discovery: Overview, current applications, and future perspectives
MT Muhammed, E Aki‐Yalcin - Chemical biology & drug design, 2019 - Wiley Online Library
Homology modeling is one of the computational structure prediction methods that are used
to determine protein 3D structure from its amino acid sequence. It is considered to be the …
to determine protein 3D structure from its amino acid sequence. It is considered to be the …
A beginner's guide to eukaryotic genome annotation
M Yandell, D Ence - Nature Reviews Genetics, 2012 - nature.com
The falling cost of genome sequencing is having a marked impact on the research
community with respect to which genomes are sequenced and how and where they are …
community with respect to which genomes are sequenced and how and where they are …
[HTML][HTML] A reference genome for pea provides insight into legume genome evolution
We report the first annotated chromosome-level reference genome assembly for pea, Gregor
Mendel's original genetic model. Phylogenetics and paleogenomics show genomic …
Mendel's original genetic model. Phylogenetics and paleogenomics show genomic …
SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information
M Biasini, S Bienert, A Waterhouse… - Nucleic acids …, 2014 - academic.oup.com
Protein structure homology modelling has become a routine technique to generate 3D
models for proteins when experimental structures are not available. Fully automated servers …
models for proteins when experimental structures are not available. Fully automated servers …
Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies
Accurate deleteriousness prediction for nonsynonymous variants is crucial for distinguishing
pathogenic mutations from background polymorphisms in whole exome sequencing (WES) …
pathogenic mutations from background polymorphisms in whole exome sequencing (WES) …
[HTML][HTML] MVP predicts the pathogenicity of missense variants by deep learning
Accurate pathogenicity prediction of missense variants is critically important in genetic
studies and clinical diagnosis. Previously published prediction methods have facilitated the …
studies and clinical diagnosis. Previously published prediction methods have facilitated the …
STRING v9. 1: protein-protein interaction networks, with increased coverage and integration
A Franceschini, D Szklarczyk, S Frankild… - Nucleic acids …, 2012 - academic.oup.com
Complete knowledge of all direct and indirect interactions between proteins in a given cell
would represent an important milestone towards a comprehensive description of cellular …
would represent an important milestone towards a comprehensive description of cellular …
[HTML][HTML] Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Ticks transmit more pathogens to humans and animals than any other arthropod. We
describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors …
describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors …
Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle
The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in
domestic cattle while at the same time considering animal health and welfare by providing …
domestic cattle while at the same time considering animal health and welfare by providing …
[HTML][HTML] Punctuated evolution of prostate cancer genomes
The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes,
but the spectrum of genome-wide alterations has not been profiled extensively in this …
but the spectrum of genome-wide alterations has not been profiled extensively in this …