Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Intracellular Ca 2+ is one of the crucial signalings that modulate various cellular functions.
The dysregulation of Ca 2+ homeostasis has been suggested as an important event in …

Store-operated Ca2+ entry (SOCE) is the principal Ca2+ entry mechanism in nonexcitable
cells. Stromal-interaction molecule 1 (STIM1) is an endoplasmic reticulum Ca2+ sensor that …

Glioblastoma (GB) is a highly invasive and lethal brain tumor due to its universal recurrence.
Although it has been suggested that the electroneutral Na+-K+-Cl− cotransporter 1 (NKCC1) …

A hallmark of high-grade cancers is the ability of malignant cells to invade unaffected tissue
and spread disease. This is particularly apparent in gliomas, the most common and lethal …

Weighted correlation network analysis (WGCNA) is a statistical method that has been widely
used in recent years to explore gene co-expression modules. Competing endogenous RNA …

During tumor progression cells acquire an altered metabolism, either as a cause or as a
consequence of an increased need of energy and nutrients. All four major classes of …

The coordination of growth during development establishes proportionality within and
among the different anatomic structures of organisms. Innate memory of this proportionality …

GABA depolarizes and excites central neurons during early development, becoming
inhibitory and hyperpolarizing with maturation. This “developmental shift” occurs abruptly …

The concentration of intracellular and extracellular potassium is tightly regulated due to the
action of various ion transporters, channels, and pumps, which reside primarily in the kidney …