Chronic wounds

V Falanga, RR Isseroff, AM Soulika… - Nature Reviews …, 2022 - nature.com
Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

[HTML][HTML] Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing

S Patel, S Srivastava, MR Singh, D Singh - Biomedicine & …, 2019 - Elsevier
Wound management in diabetic patient is of an extreme clinical and social concern. The
delayed and impaired healing makes it more critical for research focus. The research on …

Therapeutic strategies for enhancing angiogenesis in wound healing

AP Veith, K Henderson, A Spencer, AD Sligar… - Advanced drug delivery …, 2019 - Elsevier
The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

The production and application of hydrogels for wound management: A review

A Gupta, M Kowalczuk, W Heaselgrave… - European Polymer …, 2019 - Elsevier
Wound treatment has increased in importance in the wound care sector due to the
pervasiveness of chronic wounds in the high-risk population including, but not limited to …

An antibacterial and proangiogenic double-layer drug-loaded microneedle patch for accelerating diabetic wound healing

S Gao, W Zhang, X Zhai, X Zhao, J Wang… - Biomaterials …, 2023 - pubs.rsc.org
Diabetic wounds are difficult to heal because of bacterial infections and insufficient
angiogenesis. Herein, we report a double-layer drug-loaded microneedle patch with …

[Retracted] Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting …

J Ding, X Wang, B Chen, J Zhang… - BioMed research …, 2019 - Wiley Online Library
The exosomes are derived from mesenchymal stem cells (MSCs) and may be potentially
used as an alternative for cell therapy, for treating diabetic wounds, and aid in angiogenesis …

[HTML][HTML] Exosomes derived from human endothelial progenitor cells accelerate cutaneous wound healing by promoting angiogenesis through Erk1/2 signaling

J Zhang, C Chen, B Hu, X Niu, X Liu… - … journal of biological …, 2016 - ncbi.nlm.nih.gov
Chronic skin wounds represent one of the most common and disabling complications of
diabetes. Endothelial progenitor cells (EPCs) are precursors of endothelial cells and can …

Diabetic foot ulcers: current advances in antimicrobial therapies and emerging treatments

JM Ramirez-Acuña, SA Cardenas-Cadena… - Antibiotics, 2019 - mdpi.com
Diabetic foot ulcers (DFUs) are very important diabetes-related lesions that can lead to
serious physical consequences like amputations of limbs and equally severe social …

Mild-temperature photothermal effect triggers simultaneous nitric oxide-and deferoxamine-releasing mesoporous polydopamine-based nanoplatform for robust …

W Liu, X Song, W Liu, Q Lin, R Xu, H Li… - Chemistry of …, 2022 - ACS Publications
Currently, treatment of chronically infected wounds still remains a big challenge; thus, a
novel strategy with a highly efficient therapeutic effect is of urgent demand. In the present …

Injectable conductive and angiogenic hydrogels for chronic diabetic wound treatment

C Wu, L Long, Y Zhang, Y Xu, Y Lu, Z Yang… - Journal of Controlled …, 2022 - Elsevier
Chronic diabetic wounds are lack of angiogenesis and susceptible to bacterial infections
due to their high sugar microenvironment, making them difficult to heal. Here, a conductive …