Histone acetylation marks are written by histone acetyltransferases (HATs) and read by
bromodomains (BrDs), and less commonly by other protein modules. These proteins …

To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …

Because the p300/CBP-mediated hyperacetylation of RelA (p65) is critical for nuclear factor-
κB (NF-κB) activation, the attenuation of p65 acetylation is a potential molecular target for the …

Post-translational modifications, such as acetylation or phosphorylation, play a crucial role in
the regulation of gene transcription in eukaryotes. Different subtypes of histone acetyl …

HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore
compartment in CD4+ T cells. However, the genomic features of these genes and the …

Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral
DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses …

The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

The prokaryotic translation elongation factors were identified as essential cofactors for RNA-
dependent RNA polymerase activity of the bacteriophage Qβ more than 40 years ago. A …

Lysine acetylation (Kac), an abundant post-translational modification (PTM) in prokaryotes,
regulates various microbial metabolic pathways. However, no studies have examined …

Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular
homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases …