Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …

Airway remodeling comprises the structural changes of airway walls, induced by repeated
injury and repair processes. It is characterized by the changes of tissue, cellular, and …

Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of
the lung associated with structural “remodeling” inappropriate to the maintenance of normal …

Leukotrienes, a class of arachidonic acid–derived bioactive molecules, are known as
mediators of allergic and inflammatory reactions and considered to be important drug …

Background Anti‐leukotrienes (5‐lipoxygenase inhibitors and leukotriene receptors
antagonists) serve as alternative monotherapy to inhaled corticosteroids (ICS) in the …

Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is
responsible for acute bronchoconstriction, which is potentiated by constrictor …

Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth
muscle (ASM) functions including contraction, growth, and" synthetic" functions that …

Airway inflammation and remodeling in chronic asthma are characterized by airway
eosinophilia, hyperplasia of goblet cells and smooth muscle, and subepithelial fibrosis. We …

Background Patients with asthma who have aspirin sensitivity have greater cysteinyl
leukotriene production and greater airway hyperresponsiveness to the effects of inhaled …

The cysteinyl leukotrienes (cys-LTs) are a family of potent bioactive lipids that act through
two structurally divergent G protein-coupled receptors, termed the CysLT1 and CysLT2 …