Some pathogenic or symbiotic Gram-negative bacteria can manipulate the ubiquitination
system of the eukaryotic host cell using a variety of strategies. Members of the genera …

Arrhythmogenic cardiomyopathy (ACM) is an inherited progressive cardiac disease. Many
patients with ACM harbor mutations in desmosomal genes, predominantly in plakophilin-2 …

Ubiquitination has emerged as an essential signaling mechanism in eukaryotes.
Deubiquitinases (DUBs) counteract the activities of the ubiquitination machinery and provide …

As one of the most common post-translational modifications, ubiquitination regulates the
quantity and function of a variety of proteins. Experimental and clinical investigations have …

Several neurodegenerative diseases including Alzheimer's Disease (AD) are characterized
by ubiquitin‐positive pathological protein aggregates. Here, an immunoaffinity approach is …

Protein ubiquitylation, one of the most prevalent post-translational modifications in
eukaryotes, is involved in regulating nearly every cellular signaling pathway. The vast …

Mass spectrometry (MS)-based proteomic profiling of whole proteome and protein
posttranslational modifications (PTMs) is a powerful technology to measure the dynamics of …

Simultaneous inhibition of the two major constitutive protein quality control (PQC) pathways,
that is, the ubiquitin-proteasome system (UPS) and the aggresome-autophagy system, has …

The attachment of one or more ubiquitin moieties to proteins plays a central regulatory
mechanism in eukaryotic cells. Protein ubiquitylation regulates numerous cellular …

This review describes some of the more interesting and imaginative ways in which mass
spectrometry has been utilized to study a number of important post‐translational …