Multiple eukaryotic cell processes are modulated by calcium ions (Ca 2+). As such, Ca 2+ is
emerging as a crucial regulator of innate immunity in multicellular organisms. In particular …

Regulation of endosomal Toll-like receptor (TLR) responses by the chemokine CXCL4 is
implicated in inflammatory and fibrotic diseases, with CXCL4 proposed to potentiate TLR …

Ulcerative colitis (UC) is a complicated and recurrent intestinal disease. Currently available
drugs for UC treatment are scarce, therefore, novel therapeutic drugs for the UC are urgently …

Macrophage infiltration in mammary tumors is associated with enhanced tumor progression,
metastasis, and poor clinical outcome, and considered as target for therapeutic intervention …

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays an essential role in
regulating cell proliferation, migration and invasion through both kinase-dependent …

Background: Ulcerative colitis is characterized by relapsing inflammation in the
gastrointestinal tract with limited treatment options. The aim of the present study was to …

Neutrophils participate in the pathogenesis of ulcerative colitis (UC) through regulating the
intestinal homeostasis. Several inflammatory diseases are reported to be regulated by …

Abstract Two series of 2, 4-diarylaminopyrimidine derivatives containing sulfonamide moiety
were designed and synthesized for screening as inhibitors of focal adhesion kinase (FAK) …

Background Myeloid cells, including monocytes, macrophages, microglia, dendritic cells and
neutrophils are a part of innate immunity, playing a major role in orchestrating innate and …

Simple Summary Meishan pig is a local pig breed in China, which has higher immunity than
commercial pig breeds for some diseases. The spleen has hematopoietic and immune …