Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

The mitochondrial network is not only required for the production of energy, essential
cofactors and amino acids, but also serves as a signaling hub for innate immune and …

Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …

Mitochondria are highly dynamic organelles and their proper function is crucial for the
maintenance of cellular homeostasis. Mitochondrial biogenesis and mitophagy are two …

Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They
import more than 1,000 different proteins from the cytosol. It had been assumed that the …

The origin of contemporary Europeans remains contentious. We obtained a genome
sequence from Kostenki 14 in European Russia dating from 38,700 to 36,200 years ago …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

Astrocyte-neuron interactions protect neurons from iron-mediated toxicity. As dopamine can
be metabolized to reactive quinones, dopaminergic neurons are susceptible to oxidative …

Protein import into mitochondria is a highly regulated process, yet how cells clear
mitochondria undergoing dysfunctional protein import remains poorly characterized. Here …