Does the shape of the electric pulse matter in electroporation?

V Novickij, N Rembiałkowska, W Szlasa… - Frontiers in …, 2022 - frontiersin.org
Electric pulses are widely used in biology, medicine, industry, and food processing.
Numerous studies indicate that electroporation (EP) is a pulse-dependent process, and the …

Electroporation, electrochemotherapy and electro-assisted drug delivery in cancer. A state-of-the-art review

I Tsoneva, S Semkova, R Bakalova, Z Zhelev… - Biophysical …, 2022 - Elsevier
This review focuses on electrochemotherapy that consists in the delivery of anti-cancer
drugs using high-voltage electrical pulses. Technical issues, choice of drugs, and protocol of …

Electroporation enhances bleomycin efficacy in cats with periocular carcinoma and advanced squamous cell carcinoma of the head

EP Spugnini, M Pizzuto, M Filipponi… - Journal of Veterinary …, 2015 - Wiley Online Library
Background Advanced carcinoma of the head represents a substantial health problem in
cats for local control and overall survival. Objectives Evaluate the capability of …

Characterization and potential antitumor effect of a heteropolysaccharide produced by the red alga Porphyridium sordidum

B Nikolova, S Semkova, I Tsoneva… - Engineering in Life …, 2019 - Wiley Online Library
Taking into account the rising trend of the incidence of cancers of various organs, effective
therapies are urgently needed to control human malignancies. However, almost all …

Ultrasound and microbubbles mediated bleomycin delivery in feline oral squamous cell carcinoma—An in vivo veterinary study

JS de Maar, MMJM Zandvliet, S Veraa… - Pharmaceutics, 2023 - mdpi.com
To investigate the feasibility and tolerability of ultrasound and microbubbles (USMB)-
enhanced chemotherapy delivery for head and neck cancer, we performed a veterinary trial …

Redox-related molecular mechanism of sensitizing colon cancer cells to camptothecin analog SN38

B Nikolova, S Semkova, I Tsoneva… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: The aim of this study was to elucidate the possibility of sensitizing colon
cancer cells to the chemotherapeutic drug SN38 and investigate its mechanism of action …

Boundary integral formulation and semi-implicit scheme coupling for modeling cells under electrical stimulation

F Henríquez, C Jerez-Hanckes, F Altermatt - Numerische Mathematik, 2017 - Springer
We model the electrical activity of biological cells under external stimuli via a novel
boundary integral (BI) formulation together with a suitable time-space numerical …

Passive and electro-assisted delivery of hydrogel nanoparticles in solid tumors, visualized by optical and magnetic resonance imaging in vivo

R Bakalova, B Nikolova, S Murayama… - Analytical and …, 2016 - Springer
The present study describes a development of nanohydrogel, loaded with QD 705 and
manganese (QD 705@ Nanogel and QD 705@ Mn@ Nanogel), and its passive and electro …

Multiple traces formulation and semi-implicit scheme for modelling biological cells under electrical stimulation

F Henríquez, C Jerez-Hanckes - ESAIM: Mathematical Modelling and …, 2018 - numdam.org
We model the electrical behavior of several biological cells under external stimuli by
extending and computationally improving the multiple traces formulation introduced in …

The investigation of Pulse-Modulated GSM-900 MHz electromagnetic field effects on the electrochemotherapy mechanisms in vivo

M Mansourian, SMP Firoozabadi… - … Biology and Medicine, 2022 - Taylor & Francis
Electrochemotherapy (ECT) as a tumor treatment modality is approved for cutaneous and
subcutaneous tumors. The purpose of the present study was to examine the effect of 900 …