Pyrazole containing natural products: Synthetic preview and biological significance

V Kumar, K Kaur, GK Gupta, AK Sharma - European Journal of Medicinal …, 2013 - Elsevier
A large number of structurally diverse natural compounds containing azole nucleus
constitute an important class of biologically active heterocycles that are gaining more …

From 2000 to mid-2010: A fruitful decade for the synthesis of pyrazoles

S Fustero, M Sanchez-Rosello, P Barrio… - Chemical …, 2011 - ACS Publications
In the past decade, interest in pyrazole chemistry has significatively increased mainly due to
the discovery of the interesting properties exhibited by a great number of pyrazole …

A review on solvent-free methods in organic synthesis

S Zangade, P Patil - Current Organic Chemistry, 2019 - ingentaconnect.com
Most of the synthetic chemical transformation reactions involve the use of different organic
solvents. Unfortunately, some of these toxic solvents are used in chemical laboratory …

I2-Mediated Oxidative C–N Bond Formation for Metal-Free One-Pot Synthesis of Di-, Tri-, and Tetrasubstituted Pyrazoles from α,β-Unsaturated Aldehydes/Ketones …

X Zhang, J Kang, P Niu, J Wu, W Yu… - The Journal of organic …, 2014 - ACS Publications
An I2-mediated metal-free oxidative C–N bond formation methodology has been established
for the regioselective pyrazole synthesis. This practical and eco-friendly one-pot protocol …

Chalcones as Versatile Synthons for the Synthesis of 5-and 6-membered Nitrogen Heterocycles

H MT Albuquerque, C MM Santos… - Current Organic …, 2014 - ingentaconnect.com
Chalcones belong to the flavonoid family which constitutes one of the major classes of
naturally occurring oxygen heterocyclic compounds. The α, β-unsaturated carbonyl system …

[HTML][HTML] Simple and solvent free practical procedure for chalcones: An expeditious, mild and greener approach

D Adnan, B Singh, SK Mehta, V Kumar… - Current Research in …, 2020 - Elsevier
An extremely simple, expeditious and greener synthetic method for a variety of chalcone
derivatives (3) under mild and solvent free reaction conditions has been developed. The …

Ring Opening of Pyrrolinium Ions Enabled Regioselective Synthesis of 4-Alkyl N-Arylpyrazoles

S Dwari, PP Nath, CK Jana - The Journal of Organic Chemistry, 2022 - ACS Publications
An unprecedented method for the regioselective synthesis of 1, 3-diaryl 4-alkyl pyrazoles
has been reported. A wide variety of 1, 3-diaryl 4-alkyl pyrazoles were synthesized as a …

Nature and hierarchy of hydrogen-bonding interactions in binary complexes of azoles with water and hydrogen peroxide

N Chopra, D Kaur, G Chopra - ACS omega, 2018 - ACS Publications
In the present study, the hydrogen-bonded complexes of azole with water and hydrogen
peroxide are systematically investigated by second-order Møller–Plesset perturbation theory …

Exploration of chalcones and related heterocycle compounds as ligands of adenosine receptors: therapeutics development

C Matthee, G Terre'Blanche, LJ Legoabe… - Molecular Diversity, 2022 - Springer
Adenosine receptors (ARs) are ubiquitously distributed throughout the mammalian body
where they are involved in an extensive list of physiological and pathological processes that …

Iodobenzene diacetate mediated oxidation of N-substituted hydrazones of chalcones: an efficient regioselective synthesis of 1, 3, 5-trisubstituted pyrazoles

R Aggarwal, R Kumar - Synthetic Communications®, 2009 - Taylor & Francis
Full article: Iodobenzene Diacetate Mediated Oxidation of N-Substituted Hydrazones of
Chalcones: An Efficient Regioselective Synthesis of 1,3,5-Trisubstituted Pyrazoles Skip to Main …