Secreted proteins as a fundamental source for biomarker discovery

M Stastna, JE Van Eyk - Proteomics, 2012 - Wiley Online Library
The proteins secreted by various cells (the secretomes) are a potential rich source of
biomarkers as they reflect various states of the cells at real time and at given conditions. To …

Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease

V Lygirou, A Latosinska, M Makridakis… - Journal of Translational …, 2018 - Springer
Background Cardiovascular disease (CVD) describes the pathological conditions of the
heart and blood vessels. Despite the large number of studies on CVD and its etiology, its key …

In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

M Adamcová, T Šimůnek, H Kaiserová, O Popelová… - Toxicology, 2007 - Elsevier
Cardiac troponin T (cTnT) and troponin I (cTnI) are becoming acknowledged as useful
biochemical markers of drug-induced cardiotoxicity. In this study we examined the release …

Egr-1 mediated cardiac miR-99 family expression diverges physiological hypertrophy from pathological hypertrophy

S Ramasamy, G Velmurugan, B Rekha… - Experimental cell …, 2018 - Elsevier
The physiological cardiac hypertrophy is an adaptive condition without myocyte cell death,
while pathological hypertrophy is a maladaptive condition associated with myocyte cell …

Circulating acute phase proteins in relation to extent and composition of coronary atherosclerosis and cardiovascular outcome: results from the ATHEROREMO-IVUS …

LC Battes, KM Akkerhuis, JM Cheng… - International journal of …, 2014 - Elsevier
Introduction We examined whether the acute phase proteins (APPs): Alpha-1-Antitrypsin,
Alpha-2-Macroglobulin, Complement C3, ferritin, haptoglobin, and Plasminogen Activator …

High alpha-2-macroglobulin levels are a risk factor for cardiovascular disease events: A Moli-sani cohort study

R de Laat-Kremers, S Costanzo, Q Yan… - Thrombosis …, 2024 - Elsevier
Abstract Background α 2-macroglobulin (α 2 M) is a versatile endopeptidase inhibitor that
plays a role in cell growth, inflammation and coagulation. α 2 M is an inhibitor of key …

Preferential recognition of epitopes on peroxynitrite-modified alpha-2-macroglobulin by circulating autoantibodies in rheumatoid arthritis patients

HI Malik, AR Mir, M Abidi, S Habib… - Journal of Biomolecular …, 2020 - Taylor & Francis
Autoimmune responses against post-translationally modified antigens are a hallmark of
several autoimmune diseases. In this work, we have studied the changes in alpha-2 …

Proteomic characterization of serum proteins from Atlantic salmon (Salmo salar L.) from an outbreak with cardiomyopathy syndrome

JZ Costa, J Del Pozo, K McLean, N Inglis… - Journal of Fish …, 2021 - Wiley Online Library
Cardiomyopathy syndrome (CMS), caused by piscine myocarditis virus (PMCV), is a serious
challenge to Atlantic salmon (Salmo salar L.) aquaculture. Regrettably, husbandry …

Cardiac isoform of alpha 2 macroglobulin and its reliability as a cardiac marker in HIV patients

R Subbiah, V Chengat, JD Clifton, A Rathinavel… - Heart, Lung and …, 2010 - Elsevier
BACKGROUND: Cardiac isoform of alpha 2 macroglobulin (CA2M), a serum protein
(182000Mr) has been used as a diagnostic molecular marker for cardiac manifestations in …

Cardiac isoform of alpha 2 macroglobulin: a marker of cardiac involvement in pediatric HIV and AIDS

R Meenakshisundaram, S Sweni… - Pediatric …, 2010 - Springer
Cardiac involvement in children with human immunodeficiency virus (HIV)/acquired immune
deficiency syndrome (AIDS) is known but less often considered. Our objectives were to …