Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …

Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

The epigenetic regulation of DNA-templated processes has been intensely studied over the
last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA …

Interactions between biomolecules underlie all cellular processes and ultimately control cell
fate. Perturbation of native interactions through mutation, changes in expression levels or …

Transcription factors (TFs) regulate gene expression through chromatin where nucleosomes
restrict DNA access. To study how TFs bind nucleosome-occupied motifs, we focused on the …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that
regulate genomic architecture. Here, we present a structural model of the endogenously …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …