An update on the physiological and therapeutic relevance of GPCR oligomers

B Farran - Pharmacological research, 2017 - Elsevier
The traditional view on GPCRs held that they function as single monomeric units composed
of identical subunits. This notion was overturned by the discovery that GPCRs can form …

Functions of intrinsic disorder in transmembrane proteins

M Kjaergaard, BB Kragelund - Cellular and Molecular Life Sciences, 2017 - Springer
Intrinsic disorder is common in integral membrane proteins, particularly in the intracellular
domains. Despite this observation, these domains are not always recognized as being …

ELM 2016—data update and new functionality of the eukaryotic linear motif resource

H Dinkel, K Van Roey, S Michael, M Kumar… - Nucleic acids …, 2016 - academic.oup.com
Abstract The Eukaryotic Linear Motif (ELM) resource (http://elm. eu. org) is a manually
curated database of short linear motifs (SLiMs). In this update, we present the latest …

Intrinsically disordered proteins link alternative splicing and post-translational modifications to complex cell signaling and reulation

J Zhou, S Zhao, AK Dunker - Biophysical Journal, 2018 - cell.com
Intrinsically disordered regions (IDRs) make up ca. 30% of the proteome of most eukaryotes,
and are involved in a diverse set of functions. Conventional sequence alignment tools …

Structured and disordered facets of the GPCR fold

AJ Venkatakrishnan, T Flock, DE Prado… - Current Opinion in …, 2014 - Elsevier
Highlights•The relative arrangement of the transmembrane helices is conserved across
GPCR classes.•GPCR activation can be regulated from varying depths in the …

Receptor-receptor interactions as a widespread phenomenon: novel targets for drug development?

D Guidolin, M Marcoli, C Tortorella, G Maura… - Frontiers in …, 2019 - frontiersin.org
The discovery of receptor-receptor interactions (RRI) has expanded our understanding of
the role that G protein-coupled receptors (GPCRs) play in intercellular communication. The …

The listeriolysin O PEST-like sequence co-opts AP-2-mediated endocytosis to prevent plasma membrane damage during Listeria infection

C Chen, BN Nguyen, G Mitchell, SR Margolis, D Ma… - Cell host & …, 2018 - cell.com
Listeriolysin O (LLO) is a cholesterol-dependent cytolysin that mediates escape of Listeria
monocytogenes from a phagosome, enabling growth of the bacteria in the host cell cytosol …

Homo-oligomerization of the human adenosine A2A receptor is driven by the intrinsically disordered C-terminus

KDQ Nguyen, M Vigers, E Sefah, S Seppälä… - Elife, 2021 - elifesciences.org
G protein-coupled receptors (GPCRs) have long been shown to exist as oligomers with
functional properties distinct from those of the monomeric counterparts, but the driving …

G protein-coupled receptor-receptor interactions give integrative dynamics to intercellular communication

D Guidolin, M Marcoli, C Tortorella, G Maura… - Reviews in the …, 2018 - degruyter.com
The proposal of receptor-receptor interactions (RRIs) in the early 1980s broadened the view
on the role of G protein-coupled receptors (GPCR) in the dynamics of the intercellular …

[HTML][HTML] Modulation of adenosine A2a receptor oligomerization by receptor activation and PIP2 interactions

W Song, AL Duncan, MSP Sansom - Structure, 2021 - cell.com
GPCRs have been shown to form oligomers, which generate distinctive signaling outcomes.
However, the structural nature of the oligomerization process remains uncertain. We have …