Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhea, and is responsible for a spectrum of diseases characterized by high levels of …

Bacterial surface (S) layers are the outermost proteinaceous cell envelope structures found
on members of nearly all taxonomic groups of bacteria and Archaea. They are composed of …

Abstract Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the
leading cause of antibiotic-associated diarrhea worldwide. However, the key events in …

We determined the complete genome sequence of Clostridium difficile strain 630, a virulent
and multidrug-resistant strain. Our analysis indicates that a large proportion (11%) of the …

Bacteria within biofilms are protected from multiple stresses, including immune responses
and antimicrobial agents. The biofilm-forming ability of bacterial pathogens has been …

Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers
the cell surface and plays crucial roles in cell physiology. Here, we report the crystal …

Clostridium difficile is an anaerobic, spore-forming, gram-positive rod that causes a
spectrum of antibiotic-associated colitis through the elaboration of two large clostridial toxins …

Clostridium difficile infection is the leading cause of antibiotic-and healthcare-associated
diarrhea, and its containment and treatment imposes a significant financial burden …

Protein translocation across the cytoplasmic membrane is an essential process in all
bacteria. The Sec system, comprising at its core an ATPase, SecA, and a membrane …

Clostridium difficile is the prominent etiological agent of healthcare-associated diarrhea. The
disease symptoms range from mild diarrhea to life-threatening pseudomembranous colitis …