If the atmosphere of the early Earth was hydrogen-rich, 1 it is reasonable to think that
hydrogenases, the enzymes enabling cells to use molecular hydrogen, were probably …

The broad range of cellular activities carried out by Fe–S proteins means that they have a
central role in the life of most organisms. At the interface between biology and chemistry …

SUMMARY Iron-sulfur (Fe-S) clusters are required for critical biochemical pathways,
including respiration, photosynthesis, and nitrogen fixation. Assembly of these iron cofactors …

Most eukaryotes contain iron-sulfur cluster (ISC) assembly proteins related to
Saccharomyces cerevisiae Isa1 and Isa2. We show here that Isa1 but not Isa2 can be …

The ferric uptake regulator (Fur) is a global transcription factor that regulates intracellular
iron homeostasis in bacteria. The current hypothesis states that when the intracellular" free" …

Understanding the biogenesis of iron–sulfur (Fe–S) proteins is relevant to many fields,
including bioenergetics, gene regulation, and cancer research. Several multiprotein …

Bacteria use three distinct systems for iron-sulfur (Fe/S) cluster biogenesis: the ISC, SUF,
and NIF machineries. The ISC and SUF systems are widely distributed, and many bacteria …

Cysteine desulfurases are pyridoxal 5′-phosphate-dependent homodimeric enzymes that
catalyze the conversion of L-cysteine to L-alanine and sulfane sulfur via the formation of a …

These sulfur-rich chelators, being important in metal ion homeostasis, find increasing
attention. MILS-5, written by 30 internationally recognized experts, focuses on this hot topic …

Iron–sulfur (Fe–S) clusters are protein cofactors of a multitude of enzymes performing
essential biological functions. Specialized multi-protein machineries present in all types of …