Multitargeted anti-infective drugs: Resilience to resistance in the antimicrobial resistance era
CJ Suckling, IS Hunter, FJ Scott - Future drug discovery, 2022 - Taylor & Francis
The standard drug discovery paradigm of single molecule–single biological target–single
biological effect is perhaps particularly unsuitable for anti-infective drug discovery. This is …
biological effect is perhaps particularly unsuitable for anti-infective drug discovery. This is …
Insights into the spectrum of activity and mechanism of action of MGB-BP-3
MGB-BP-3 is a potential first-in-class antibiotic, a Strathclyde Minor Groove Binder (S-MGB),
that has successfully completed Phase IIa clinical trials for the treatment of Clostridioides …
that has successfully completed Phase IIa clinical trials for the treatment of Clostridioides …
The allure of targets for novel drugs
CJ Suckling - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
The challenges of bringing new medicines to patients have been extensively discussed and
debated, including consideration of the contribution that academic laboratories can make. At …
debated, including consideration of the contribution that academic laboratories can make. At …
Strathclyde minor groove binders (S-MGBs) with activity against Acanthamoeba castellanii
LMC Mcgee, AG Carpinteyro Sanchez… - Journal of …, 2024 - academic.oup.com
Background Acanthamoeba spp. is the causative agent of Acanthamoeba keratitis and
granulomatous amoebic encephalitis. Strathclyde minor groove binders (S-MGBs) are a …
granulomatous amoebic encephalitis. Strathclyde minor groove binders (S-MGBs) are a …
MptpB Inhibitor Improves the Action of Antibiotics against Mycobacterium tuberculosis and Nontuberculous Mycobacterium avium Infections
P Rodríguez-Fernández, L Botella… - ACS Infectious …, 2023 - ACS Publications
Treatment of Mycobacterium tuberculosis and Mycobacterium avium infections requires
multiple drugs for long time periods. Mycobacterium protein-tyrosine-phosphatase B (MptpB) …
multiple drugs for long time periods. Mycobacterium protein-tyrosine-phosphatase B (MptpB) …
Furamidine-induced autophagy exerts an anti-mycobacterial effect in a SIRT1-pAMPK-FOXO3a-dependent manner by elevation of intracellular Ca2+ level expression
Abstract Mycobacterium tuberculosis (M. tb), the etiological agent of tuberculosis (TB),
continues to be a major contributor to global mortality rates. To effectively combat this …
continues to be a major contributor to global mortality rates. To effectively combat this …
Selective anti-leishmanial strathclyde minor groove binders using an N-oxide tail-group modification
MC Perieteanu, LMC McGee, CD Shaw… - International Journal of …, 2022 - mdpi.com
The neglected tropical disease leishmaniasis, caused by Leishmania spp., is becoming
more problematic due to the emergence of drug-resistant strains. Therefore, new drugs to …
more problematic due to the emergence of drug-resistant strains. Therefore, new drugs to …
S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents
M Perieteanu, TR Garzon, LMC McGee… - RSC Medicinal …, 2025 - pubs.rsc.org
There were an estimated 249 million cases of malaria globally in 2022, causing
approximately 608 000 deaths. Most of these are attributed to infection by P. falciparum …
approximately 608 000 deaths. Most of these are attributed to infection by P. falciparum …