HOTGpred: Enhancing human O-linked threonine glycosylation prediction using integrated pretrained protein language model-based features and multi-stage feature …

NT Pham, Y Zhang, R Rakkiyappan… - Computers in Biology and …, 2024 - Elsevier
O-linked glycosylation is a complex post-translational modification (PTM) in human proteins
that plays a critical role in regulating various cellular metabolic and signaling pathways. In …

Maintaining barrier function of infected gingival epithelial cells by inhibition of DNA methylation

SP Barros, E Hefni, F Fahimipour… - Journal of …, 2020 - Wiley Online Library
Background Infection and inflammation induce epigenetic changes that alter gene
expression. In periodontal disease, inflammation, and microbial dysbiosis occur, which can …

O-GlyThr: Prediction of human O-linked threonine glycosites using multi-feature fusion

H Tang, Q Tang, Q Zhang, P Feng - International Journal of Biological …, 2023 - Elsevier
O-linked glycosylation is one of the most complex post-translational modifications (PTM) of
human proteins modulating various cellular metabolic and signaling pathways. Unlike N …

Model-based in silico analysis of the PI3K/Akt pathway: the elucidation of cross-talk between diabetes and breast cancer

S Rehman, A Obaid, A Naz, A Ali, S Kanwal, J Ahmad - PeerJ, 2018 - peerj.com
Background A positive association between diabetes and breast cancer has been identified
by various epidemiological and clinical studies. However, the possible molecular …

Functional Regulation Between Matrix Metalloproteases and Cell Junction Proteins in Gastric Cancer

T Roy, VK Mishra, S Mallick, S Swarnakar - Handbook of Oxidative Stress …, 2022 - Springer
Gastric cancer (GC) is one of the most frequent malignancies of the digestive tract
worldwide. The tumor microenvironment plays a key role in the complex process of GC …