Ethnobotany and the role of plant natural products in antibiotic drug discovery

G Porras, F Chassagne, JT Lyles, L Marquez… - Chemical …, 2020 - ACS Publications
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …

TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis

NN Kuzmich, KV Sivak, VN Chubarev, YB Porozov… - Vaccines, 2017 - mdpi.com
Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate
immune response and its activation by bacterial endotoxin is responsible for chronic and …

Thymoquinone and its therapeutic potentials

S Darakhshan, AB Pour, AH Colagar… - Pharmacological …, 2015 - Elsevier
Herbal medicine has attracted great attention in the recent years and is increasingly used as
alternatives to chemical drugs. Several lines of evidence support the positive impact of …

Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation

K Chaieb, B Kouidhi, H Jrah, K Mahdouani… - … and alternative medicine, 2011 - Springer
Background Thymoquinone is an active principle of Nigella sativa seed known as" Habbah
Al-Sauda" in Arabic countries and" Sinouj" in Tunisia. Bacterial biofilms tend to exhibit …

The neuroprotective effects of thymoquinone: a review

T Farkhondeh, S Samarghandian… - Dose …, 2018 - journals.sagepub.com
Thymoquinone (TQ), one of the main components active of Nigella sativa, exhibited very
useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic …

[HTML][HTML] Black seed (Nigella sativa) and its constituent thymoquinone as an antidote or a protective agent against natural or chemical toxicities

A Tavakkoli, A Ahmadi, BM Razavi… - Iranian journal of …, 2017 - ncbi.nlm.nih.gov
Abstract Nigella sativa (N. sativa), which belongs to the botanical family of Ranunculaceae,
is a widely used medicinal plant all over the world. N. sativa seeds and oil have been used …

Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model

KM Alkharfy, A Ahmad, RMA Khan… - European journal of drug …, 2015 - Springer
Thymoquinone (THQ), the active constituent of Nigella sativa seeds, has demonstrated
some potential pharmacological activities. The present study was designed to investigate …

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

M Mekhemar, Y Hassan, C Dörfer - Antioxidants, 2020 - mdpi.com
Thymoquinone (TQ), the chief active constituent of Nigella sativa (NS), shows very valuable
biomedical properties such as antioxidant, antimicrobial, anticancer, anti-inflammatory …

A review on possible therapeutic effect of Nigella sativa and thymoquinone in neurodegenerative diseases

S Samarghandian, T Farkhondeh… - CNS & Neurological …, 2018 - ingentaconnect.com
Background & Objective: Medicinal plants have attracted great attention in the recent years
and is increasingly applied instead of the chemical drugs. Several documents showed that …

[HTML][HTML] Covid‐19 and thymoquinone: Connecting the dots

A Ahmad, MU Rehman, P Ahmad… - Phytotherapy …, 2020 - ncbi.nlm.nih.gov
FIGURE 1 Thymoquinone potential protective mechanism against Covid-19 infection.
Progression from risk factors for severe SARS-CoV-2 infection mediated by oxidative stress …