The level of glycaemic control necessary to achieve optimal short‐term and long‐term
outcomes in subjects with type 1 diabetes mellitus (T1DM) typically requires intensified …

In healthy individuals, plasma glucose concentration is tightly regulated by the action of the
hormones secreted by the endocrine pancreas, principally, insulin and glucagon. Insulin is …

In this two-part Bench to Clinic narrative, recent advances in both the preclinical and clinical
aspects of artificial pancreas (AP) development are described. In the preceding Bench …

OBJECTIVE To evaluate feasibility, safety, and efficacy of overnight closed-loop insulin
delivery in free-living youth with type 1 diabetes. RESEARCH DESIGN AND METHODS …

OBJECTIVE To evaluate the feasibility of a wearable artificial pancreas system, the Diabetes
Assistant (DiAs), which uses a smart phone as a closed-loop control platform. RESEARCH …

Background: Accurate closed-loop control is essential for developing artificial pancreas (AP)
systems that adjust insulin infusion rates from insulin pumps. Glucose concentration …

OBJECTIVE To evaluate the feasibility of day and night closed-loop insulin delivery in adults
with type 1 diabetes under free-living conditions. RESEARCH DESIGN AND METHODS …

Background: We present a clinical trial establishing the feasibility of a control-to-range (CTR)
closed-loop system informed by heart rate (HR) and assess the effect of HR information …

Closed-loop insulin delivery continues to be one of most promising strategies for achieving
near-normal control of blood glucose levels in individuals with diabetes. Of the many …

OBJECTIVE To determine the safety and efficacy of an automated unified safety system
(USS) in providing overnight closed-loop (OCL) control in children and adolescents with …