Natural history and mechanisms of COPD

P Lange, E Ahmed, ZM Lahmar, FJ Martinez… - …, 2021 - Wiley Online Library
The natural history of COPD is complex, and the disease is best understood as a syndrome
resulting from numerous interacting factors throughout the life cycle with smoking being the …

SARS-CoV-2 infection and lung regeneration

F Zhao, Q Ma, Q Yue, H Chen - Clinical Microbiology Reviews, 2022 - Am Soc Microbiol
The lung is the primary site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2)-induced immunopathology whereby the virus enters the host cells by binding to …

BMP-induced non-canonical signaling is upregulated during autophagy-mediated regeneration in inflamed mesothelial cells

V Zsiros, N Dóczi, G Petővári, A Pop, Z Erdei… - Scientific Reports, 2023 - nature.com
Previously, we showed that after Freund's adjuvant-induced peritonitis, rat mesothelial cells
regain their epithelial phenotype through mesenchymal-epithelial transition (MET) …

Repairing mechanisms for distal airway injuries and related targeted therapeutics for chronic lung diseases

H Xu, G Pan, J Wang - Cell Transplantation, 2023 - journals.sagepub.com
Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and
idiopathic pulmonary fibrosis (IPF), involve progressive and irreversible destruction and …

The diversity of adult lung epithelial stem cells and their niche in homeostasis and regeneration

Y Wang, N Tang - Science China Life Sciences, 2021 - Springer
The adult lung, a workhorse for gas exchange, is continually subjected to a barrage of
assaults from the inhaled particles and pathogens. Hence, homeostatic maintenance is of …

Inhibition of Gabrp reduces the differentiation of airway epithelial progenitor cells into goblet cells

A Wang, Q Zhang, Y Wang, X Li… - Experimental and …, 2021 - spandidos-publications.com
Bronchial asthma is an intractable pulmonary disease that affects millions of individuals
worldwide, with the overproduction of mucus contributing to high morbidity and mortality …

Lung Organoids: Systematic Review of Recent Advancements and its Future Perspectives

T Thangam, K Parthasarathy, K Supraja… - Tissue Engineering and …, 2024 - Springer
Organoids are essentially an in vitro (lab-grown) three-dimensional tissue culture system
model that meticulously replicates the structure and physiology of human organs. A few of …

Beyond (epi) genetic association studies: functional studies of COPD susceptibility genes

Q Chen - 2023 - research.rug.nl
Chronic obstructive pulmonary disease (COPD) is a disease of the lungs accompanied by
chronic inflammatory processes of the (small) airways, which is currently the third leading …

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SP Atkinson - Stem cells translational medicine, 2021 - ncbi.nlm.nih.gov
Severe blockages in arteries of the extremities can significantly reduce blood flow and
prompt the onset of critical limb ischemia. The lack of circulation induces severe pain in the …