Ion channels are integral membrane proteins whose gating has been increasingly shown to
depend on the presence of the low-abundance membrane phospholipid …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

KCNQ1, also known as Kv7. 1, is a voltage-dependent K+ channel that regulates gastric
acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are …

KCNQ1 is the pore-forming subunit of cardiac slow-delayed rectifier potassium (I Ks)
channels. Mutations in the kcnq1 gene are the leading cause of congenital long QT …

The phosphoinositide, phosphatidylinositol 4, 5-bisphosphate (PIP2), has long been
established as a major contributor to intracellular signaling, primarily by virtue of its role as a …

Kv7 channels are enriched at the axonal plasma membrane where their voltage-dependent
potassium currents suppress neuronal excitability. Mutations in Kv7. 2 and Kv7. 3 subunits …

Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a
broad range of excitable and non-excitable cell types and are found in organisms ranging …

Summary Kv7 (KCNQ) voltage-gated potassium channels control excitability in the brain,
heart, and ear. Calmodulin (CaM) is crucial for Kv7 function, but how this calcium sensor …

Zinc (Zn) is an essential trace element; it serves as a cofactor for a great number of enzymes,
transcription factors, receptors, and other proteins. Zinc is also an important signaling …

The IKs channel complex is formed by the co-assembly of Kv7. 1 (KCNQ1), a voltage-gated
potassium channel, with its β-subunit, KCNE1 and the association of numerous accessory …