Aging and oxidative stress seem to be the most important factors in the pathogenesis of age-
related macular degeneration (AMD), a condition affecting many elderly people in the …

Abstract The Base Excision Repair (BER) pathway is a highly conserved DNA repair system
targeting subtle chemical base modifications that arise from oxidation, deamination and …

Human 8-oxoguanine-DNA glycosylase (OGG1) plays a major role in the base excision
repair pathway by removing 8-oxoguanine base lesions generated by reactive oxygen …

Proliferating cell nuclear antigen (PCNA), a potential anticancer target, forms a homotrimer
and is required for DNA replication and numerous other cellular processes. The purpose of …

In germ cells undergoing meiosis, the induction of double strand breaks (DSBs) is required
for the generation of haploid gametes. Defects in the formation, detection, or …

The RAD9-RAD1-HUS1 (9-1-1) complex is a heterotrimeric PCNA-like clamp that responds
to DNA damage in somatic cells by promoting DNA repair as well as ATR-dependent DNA …

DNA glycosylases promote genomic stability by initiating base excision repair (BER) in both
the nuclear and mitochondrial genomes. Several of these enzymes have overlapping …

Abstract Background The Tousled-like kinases are involved in chromatin assembly, DNA
repair, transcription, and chromosome segregation. Previous evidence indicated that TLK1B …

MutY homologue (MYH) is a DNA glycosylase which excises adenine paired with the
oxidative lesion 7, 8-dihydro-8-oxoguanine (8-oxoG, or G o) during base excision repair …

Rad9 plays a crucial role in maintaining genomic stability by regulating cell cycle
checkpoints, DNA repair, telomere stability, and apoptosis. Rad9 controls these processes …