The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Abstract Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is
expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in …

Colorectal cancer (CRC) is a heterogeneous disease with high incidence and mortality
worldwide. The efficacy of conventional CRC chemotherapy is hampered by poor drug …

New organometallic gold (III) and platinum (II) complexes containing iminophosphorane
ligands are described. Most of them are more cytotoxic to a number of human cancer cell …

Introduction Cancer has been identified as one of the leading causes of death worldwide.
The biological target of some anticancer agents is topoisomerase I, an enzyme involved in …

Malignant tumor cells have been found to have high levels of reactive oxygen species such
as hydrogen peroxide (H 2 O 2), supporting the hypothesis that a prodrug could be activated …

The aim of this work was to investigate the potential of a new 3, 6-O, O'-dimyristoyl derivative
amphiphilic chitosan (DMCh), in improving the solubility of camptothecin (CPT), a …

Non-small-cell lung cancer (NSCLC) dominates over 85% of all lung cancer cases.
Epidermal growth factor receptor (EGFR) activating mutation is a common situation in …

The purpose of this work is to investigate the discriminatory power of the Biopharmaceutics
Classification System (BCS)-biowaiver in vitro methodology, ie, to investigate if a BCS …

Many drugs have been discontinued during phase II/III breast cancer clinical trials due to
lack of clinical efficacy, indicating shortcomings in predictive value of preclinical data …