CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses

JW Thinwa, Z Zou, E Parks, S Sebti… - The Journal of …, 2024 - Am Soc Clin Investig
Virophagy, the selective autophagosomal engulfment and lysosomal degradation of viral
components, is crucial for neuronal cell survival and antiviral immunity. However, the …

Cleavage of the selective autophagy receptor SQSTM1/p62 by the SARS-CoV-2 main protease NSP5 prevents the autophagic degradation of viral membrane proteins

Y Zhang, S Liu, Q Xu, H Li, K Lu - Molecular biomedicine, 2022 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the
coronavirus disease 2019 (COVID-19) global pandemic. Omicron, a new variant of SARS …

Starvation after infection restricts enterovirus D68 replication

A Jassey, MA Wagner, G Galitska, B Paudel, K Miller… - Autophagy, 2023 - Taylor & Francis
ABSTRACT Enterovirus D68 (EV-D68) is a respiratory pathogen associated with acute
flaccid myelitis, a childhood paralysis disease. No approved vaccine or antiviral treatment …

Non-lytic spread of poliovirus requires the nonstructural protein 3CD

D Aponte-Diaz, JM Harris, TE Kang, V Korboukh… - mBio, 2025 - journals.asm.org
Non-enveloped viruses like poliovirus (PV) have evolved the capacity to spread by non-lytic
mechanisms. For PV, this mechanism exploits the host secretory autophagy pathway …

Construction of Infectious Clones for Human Enteroviruses

T Yogarajah, JJH Chu - Reverse Genetics of RNA Viruses: Methods and …, 2023 - Springer
The infectious clone has been constructed for years via various mechanisms using reverse
genetics of viral RNA into cDNA. The mechanism of construction has evolved to DNA-launch …

CDKL5 regulates p62-mediated selective autophagy and host antiviral defense

JW Thinwa, Z Zou, E Parks, S Sebti, K Hui, Y Wei… - bioRxiv, 2022 - biorxiv.org
Virophagy, the selective autophagosomal engulfment and degradation of viral components,
is crucial for antiviral immunity. However, the mechanisms leading to viral antigen …

Check Chapter 6 updates

D Toro-Ascuy, M Cárdenas… - Reverse Genetics of …, 2023 - books.google.com
The piscine orthomyxovirus called infectious salmon anemia virus (ISAV) is one of the most
important emerging pathogens affecting the salmon industry worldwide. The first reverse …

Dynamics of Enteroviral Protease Cleavages and Implications for Antiviral Drug Development

JS Doherty - 2023 - search.proquest.com
Enteroviruses are a group of positive stranded RNA viruses that primarily infect the enteric
tract, but many species have also been associated with neurological complications …

Enterovirus Replication Organelles; function, formation and the role of viral proteins

B Coelingh - 2023 - studenttheses.uu.nl
Enteroviruses extensively manipulate cellular functions during infection. One of the most
prominent changes is in membrane morphology. Enteroviral infection causes the formation …

Effect and mechanism of PTEN on renal interstitial fibrosis in diabetic nephropathy

LIU Xing-Mei, S Yan, BAN Xiao-Xia… - Jie Fang Jun Yi Xue …, 2022 - search.proquest.com
Objective To explore the effect and mechanism of phosphatase and tensin homolog (PTEN)
on renal interstitial fibrosis in diabetic nephropathy. Methods We culture NRK52E cells in …