Unpredicted protective function of Fc-mediated inhibitory antibodies for HIV and SARS-CoV-2 vaccines
LY Lin, P Gantner, S Li, B Su… - The Journal of Infectious …, 2024 - academic.oup.com
Developing effective vaccines is necessary in combating new virus pandemics. For human
immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS …
immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS …
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies
ABSTRACT HIV-1 envelope glycoprotein (Env) conformation substantially impacts antibody-
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents
S Umemoto, R Nakahashi-Ouchida, Y Yuki… - npj Vaccines, 2023 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of upper and lower respiratory tract
infection, especially in children and the elderly. Various vaccines containing the major …
infection, especially in children and the elderly. Various vaccines containing the major …
Highly Sensitive Analysis of Cervical Mucosal HIV-1 Infection Using Reporter Viruses Expressing Secreted Nanoluciferase
DF Indihar, JJ Jones, C Ochsenbauer, JC Kappes - HIV Protocols, 2024 - Springer
Ex vivo cervical tissue explant models offer a physiologically relevant approach for studying
virus-host interactions that underlie mucosal HIV-1 transmission to women. However, the …
virus-host interactions that underlie mucosal HIV-1 transmission to women. However, the …
Evolution of antibody responses in HIV-1 CRF01_AE acute infection: founder envelope V1V2 impacts the timing and magnitude of autologous neutralizing antibodies
S Kuriakose Gift, L Wieczorek, E Sanders-Buell… - Journal of …, 2023 - Am Soc Microbiol
Understanding the dynamics of early immune responses to HIV-1 infection, including the
evolution of initial neutralizing and antibody-dependent cellular cytotoxicity (ADCC) …
evolution of initial neutralizing and antibody-dependent cellular cytotoxicity (ADCC) …
Detection of the HIV-1 Accessory Proteins Nef and Vpu by Flow Cytometry Represents a New Tool to Study Their Functional Interplay within a Single Infected CD4+ T …
ABSTRACT The HIV-1 Nef and Vpu accessory proteins are known to protect infected cells
from antibody-dependent cellular cytotoxicity (ADCC) responses by limiting exposure of …
from antibody-dependent cellular cytotoxicity (ADCC) responses by limiting exposure of …
Needle-Free Devices and CpG-Adjuvanted DNA Improve Anti-HIV Antibody Responses of Both DNA and Modified Vaccinia Ankara-Vectored Candidate Vaccines
R Chapman, M van Diepen, N Douglass, T Hermanus… - Vaccines, 2023 - mdpi.com
The combination of mosaic Gag and CAP256 envelope in an HIV vaccine regimen
comprising DNA prime and modified vaccinia Ankara (MVA) boost followed by protein boost …
comprising DNA prime and modified vaccinia Ankara (MVA) boost followed by protein boost …
Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned …
A Kenny, J van Duijn, O Dintwe, J Heptinstall… - …, 2024 - thelancet.com
Summary Background The HVTN 705 Imbokodo trial of 2636 people without HIV and
assigned female sex at birth, conducted in southern Africa, evaluated a heterologous HIV-1 …
assigned female sex at birth, conducted in southern Africa, evaluated a heterologous HIV-1 …
Innate protection against intrarectal SIV acquisition by a live SHIV vaccine
Identifying immune correlates of protection is a major challenge in AIDS vaccine
development. Anti-Envelope antibodies have been considered critical for protection against …
development. Anti-Envelope antibodies have been considered critical for protection against …
A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma …
S Dankwa, C Kosman, M Dennis, EE Giorgi, K Vuong… - PloS one, 2024 - journals.plos.org
To eliminate vertical HIV transmission and achieve therapy-free viral suppression among
children living with HIV, novel strategies beyond antiretroviral therapy (ART) are necessary …
children living with HIV, novel strategies beyond antiretroviral therapy (ART) are necessary …