We introduce and analyze a discontinuous Galerkin method for the numerical modeling of
the equations of Multiple-Network Poroelastic Theory (MPET) in the dynamic formulation …

The vascular microenvironment is the scale at which microvascular transport, interstitial
tissue properties and cell metabolism interact. The vascular microenvironment has been …

In this review, we provide a summary of the state-of-the-art in the in silico modelling of
cerebral blood flow (CBF) and its application in in silico clinical trials. CBF plays a key role in …

Cerebral perfusion modelling is a promising tool to predict the impact of acute ischaemic
stroke treatments on the spatial distribution of cerebral blood flow (CBF) in the human brain …

Abstract Models of the micro-circulatory blood flow in the brain can play a key role in
understanding the variety of cerebrovascular diseases that occur in the microvasculature …

An in silico trial simulates a disease and its corresponding therapies on a cohort of virtual
patients to support the development and evaluation of medical devices, drugs, and …

In ischaemic stroke, a large reduction in blood supply can lead to the breakdown of the
blood brain barrier and to cerebral oedema after reperfusion therapy. Cerebral oedema is …

The microvasculature plays a key role in oxygen transport in the mammalian brain. Despite
the close coupling between cerebral vascular geometry and local oxygen demand, recent …

The cerebral vasculature plays a critical role in the transport of oxygen and other nutrients to
brain tissue. However, the size, complexity, and paucity of detailed anatomical information of …

Treating retinal diseases to prevent sight loss is an increasingly important challenge. Thanks
to the configuration of the eye, the retina can be examined relatively easily in situ. Owing to …