Unraveling the role of antimicrobial peptides in insects

S Stączek, M Cytryńska… - International journal of …, 2023 - mdpi.com
Antimicrobial peptides (AMPs) are short, mainly positively charged, amphipathic molecules.
AMPs are important effectors of the immune response in insects with a broad spectrum of …

[HTML][HTML] Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

B Deslouches, YP Di - Oncotarget, 2017 - ncbi.nlm.nih.gov
In the last several decades, there have been significant advances in anticancer therapy.
However, the development of resistance to cancer drugs and the lack of specificity related to …

Tumors evade immune cytotoxicity by altering the surface topology of NK cells

X Zheng, Z Hou, Y Qian, Y Zhang, Q Cui, X Wang… - Nature …, 2023 - nature.com
The highly variable response rates to immunotherapies underscore our limited knowledge
about how tumors can manipulate immune cells. Here the membrane topology of natural …

Insect antimicrobial peptides and their applications

HY Yi, M Chowdhury, YD Huang, XQ Yu - Applied microbiology and …, 2014 - Springer
Insects are one of the major sources of antimicrobial peptides/proteins (AMPs). Since
observation of antimicrobial activity in the hemolymph of pupae from the giant silk moths …

Role of lipids in the interaction of antimicrobial peptides with membranes

V Teixeira, MJ Feio, M Bastos - Progress in lipid research, 2012 - Elsevier
Antimicrobial peptides (AMPs) take part in the immune system by mounting a first line of
defense against pathogens. Recurrent structural and functional aspects are observed …

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

MA Hanson, A Dostálová, C Ceroni, M Poidevin… - Elife, 2019 - elifesciences.org
Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading
microorganisms. These short, cationic peptides have been implicated in many biological …

[HTML][HTML] Alternatives to overcoming bacterial resistances: State-of-the-art

AC Rios, CG Moutinho, FC Pinto, FS Del Fiol… - Microbiological …, 2016 - Elsevier
Worldwide, bacterial resistance to chemical antibiotics has reached such a high level that
endangers public health. Presently, the adoption of alternative strategies that promote the …

[HTML][HTML] Membrane-active host defense peptides–challenges and perspectives for the development of novel anticancer drugs

S Riedl, D Zweytick, K Lohner - Chemistry and physics of lipids, 2011 - Elsevier
Although much progress has been achieved in the development of cancer therapies in
recent decades, problems continue to arise particularly with respect to chemotherapy due to …

Insect cecropins, antimicrobial peptides with potential therapeutic applications

D Brady, A Grapputo, O Romoli, F Sandrelli - International journal of …, 2019 - mdpi.com
The alarming escalation of infectious diseases resistant to conventional antibiotics requires
urgent global actions, including the development of new therapeutics. Antimicrobial peptides …

Clinical applications and anticancer effects of antimicrobial peptides: from bench to bedside

A Jafari, A Babajani, R Sarrami Forooshani… - Frontiers in …, 2022 - frontiersin.org
Cancer is a multifaceted global health issue and one of the leading causes of death
worldwide. In recent years, medical science has achieved great advances in the diagnosis …