Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

EM Frickel, CA Hunter - Journal of Experimental Medicine, 2021 - rupress.org
The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

GABAergic signaling by cells of the immune system: more the rule than the exception

AK Bhandage, A Barragan - Cellular and Molecular Life Sciences, 2021 - Springer
Gamma-aminobutyric acid (GABA) is best known as an essential neurotransmitter in the
evolved central nervous system (CNS) of vertebrates. However, GABA antedates the …

[HTML][HTML] Early passage of Toxoplasma gondii across the blood–brain barrier

EC Ross, GC Olivera, A Barragan - Trends in parasitology, 2022 - cell.com
The blood–brain barrier (BBB) efficiently protects the central nervous system (CNS) from
infectious insults. Yet, the apicomplexan parasite Toxoplasma gondii has a remarkable …

[HTML][HTML] The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages

AL Ten Hoeve, L Braun, ME Rodriguez, GC Olivera… - Cell host & …, 2022 - cell.com
Upon pathogen detection, macrophages normally stay sessile in tissues while dendritic cells
(DCs) migrate to secondary lymphoid tissues. The obligate intracellular protozoan …

A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites

AK Bhandage, GC Olivera, S Kanatani, E Thompson… - Elife, 2020 - elifesciences.org
Gamma-aminobutyric acid (GABA) serves diverse biological functions in prokaryotes and
eukaryotes, including neurotransmission in vertebrates. Yet, the role of GABA in the immune …

GABAergic signaling in human and murine NK cells upon challenge with Toxoplasma gondii

AK Bhandage, LM Friedrich, S Kanatani… - Journal of Leukocyte …, 2021 - academic.oup.com
Protective cytotoxic and proinflammatory cytokine responses by NK cells impact the outcome
of infections by Toxoplasma gondii, a common parasite in humans and other vertebrates …

[HTML][HTML] Met-signaling controls dendritic cell migration in skin by regulating podosome formation and function

AEI Hamouda, C Schalla, A Sechi, M Zenke… - Journal of Investigative …, 2023 - Elsevier
Signaling through the HGF receptor/Met in skin-resident Langerhans cells (LCs) and dermal
dendritic cells (DCs) is essential for their emigration toward draining lymph nodes upon …

Integrin-dependent migratory switches regulate the translocation of Toxoplasma-infected dendritic cells across brain endothelial monolayers

EC Ross, AL Ten Hoeve, A Barragan - Cellular and Molecular Life …, 2021 - Springer
Multiple cellular processes, such as immune responses and cancer cell metastasis, crucially
depend on interconvertible migration modes. However, knowledge is scarce on how …

Toxoplasma effector-induced ICAM-1 expression by infected dendritic cells potentiates transmigration across polarised endothelium

EC Ross, AL Hoeve, JPJ Saeij, A Barragan - Frontiers in Immunology, 2022 - frontiersin.org
The obligate intracellular parasite Toxoplasma gondii makes use of infected leukocytes for
systemic dissemination. Yet, how infection impacts the processes of leukocyte diapedesis …

[HTML][HTML] Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates …

AL Ten Hoeve, ME Rodriguez, M Säflund, V Michel… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Mononuclear phagocytes facilitate the dissemination of the obligate intracellular parasite
Toxoplasma gondii. Here, we report how a set of secreted parasite effector proteins from …