The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …

Neurotrophic factors comprise a broad family of biomolecules–most of which are peptides or
small proteins–that support the growth, survival and differentiation of both developing and …

Nerve growth factor (NGF) was the first neurotrophin described. This neurotrophin
contributes to organogenesis by promoting sensory innervation and angiogenesis in the …

Neurotrophic factors are growth factors that can nourish neurons and promote neuron
survival and regeneration. They have been studied as potential drug candidates for treating …

Insulin secretion by pancreatic islet β cells is critical for glucose homeostasis, and a blunted
β cell secretory response is an early deficit in type 2 diabetes. Here, we uncover a regulatory …

Personalized and regenerative medicine is an emerging therapeutic strategy that is based
on cell biology and biomedical engineering used to develop biological substitutes to …

Background The efficacy of intramuscular islet transplantation is poor despite being
technically simple, safe, and associated with reduced rates of severe complications. We …

Diabetic nephropathy (DN) is one of the leading causes of chronic kidney disease (CKD),
during which hyperglycemia is composed of the major force for the deterioration to end …

Background Encapsulation devices have the potential to enable cell-based insulin
replacement therapies (such as human islet or stem cell–derived β cell transplantation) …

Therapeutic options for amyotrophic lateral sclerosis (ALS) are still limited. Great hopes,
however, are placed in growth factors that show neuroprotective abilities (eg, nerve growth …