CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

Prevention of re-establishment (POR) refers to the prevention of malaria outbreak/epidemic
occurrence or preventing re-establishment of indigenous malaria in a malaria-free country …

Human trypanosomiasis and leishmaniasis are vector‐borne neglected tropical diseases
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …

CRISPR/Cas9 gene editing has revolutionised loss-of-function experiments in Leishmania,
the causative agent of leishmaniasis. As Leishmania lack a functional non-homologous DNA …

Malaria contributes to the most widespread infectious diseases worldwide. Even though
current drugs are commercially available, the ever-increasing drug resistance problem by …

The∼ 30 Mb genomes of the Plasmodium parasites that cause malaria each encode∼
5000 genes, but the functions of the majority remain unknown. This is due to a paucity of …

Produced amidst the still rippling effects of a pandemic and as the world experiences the
increasing burden of global warming and a rapidly changing biosphere, the second edition …

Nonsense-mediated decay (NMD) is a conserved mRNA quality control process that
eliminates transcripts bearing a premature termination codon. In addition to its role in …

CRISPR/Cas9 technology has revolutionized biology. This prokaryotic defense system
against foreign DNA has been repurposed for genome editing in a broad range of cell …

Gene editing in trypanosomatids has long been proven difficult. The development of
CRISPR-Cas9 has improved this issue, opening the way to a better understanding of …