Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease

DJR Lane, B Metselaar, M Greenough… - Essays in …, 2021 - portlandpress.com
Ferroptosis is an iron-and lipid peroxidation-dependent cell death modality and emerging
evidence indicates that ferroptosis has great explanatory potential for neuronal loss and …

[HTML][HTML] Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications

Y Qin, Y Qiao, D Wang, C Tang, G Yan - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Ferroptosis is a type of regulated cell death driven by iron dependent accumulation of
cellular reactive oxygen species (ROS) when glutathione (GSH)-dependent lipid …

FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis

Z Pei, Y Liu, S Liu, W Jin, Y Luo, M Sun, Y Duan… - Metabolism, 2021 - Elsevier
Objective Ferroptosis is indicated in cardiovascular diseases. Given the prominent role of
mitophagy in the governance of ferroptosis and our recent finding for FUN14 domain …

Ferroptosis mediated by lipid reactive oxygen species: a possible causal link of neuroinflammation to neurological disorders

Y Cheng, Y Song, H Chen, Q Li, Y Gao… - … Medicine and Cellular …, 2021 - Wiley Online Library
Increasing evidence indicates a possible causal link between neuroinflammation and
neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) …

[HTML][HTML] Research on ferroptosis as a therapeutic target for the treatment of neurodegenerative diseases

Y Wang, M Lv, W Zhao - Ageing research reviews, 2023 - Elsevier
Ferroptosis is an iron-and lipid peroxidation (LPO)-mediated programmed cell death type.
Recently, mounting evidence has indicated the involvement of ferroptosis in …

Ferroptosis in heart failure

X Yang, NK Kawasaki, J Min, T Matsui… - Journal of molecular and …, 2022 - Elsevier
With its complicated pathobiology and pathophysiology, heart failure (HF) remains an
increasingly prevalent epidemic that threatens global human health. Ferroptosis is a form of …

Ferroptosis and its role in chronic diseases

W Hu, K Liang, H Zhu, C Zhao, H Hu, S Yin - Cells, 2022 - mdpi.com
Ferroptosis, which has been widely associated with many diseases, is an iron-dependent
regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits …

[HTML][HTML] Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: a review

D Zhao, K Yang, H Guo, J Zeng, S Wang, H Xu… - Biomedicine & …, 2023 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

Empagliflozin attenuates trastuzumab-induced cardiotoxicity through suppression of DNA damage and ferroptosis

J Min, L Wu, Y Liu, G Song, Q Deng, W Jin, W Yu… - Life Sciences, 2023 - Elsevier
Trastuzumab (TZM) is commonly used for target therapy in breast cancer patients with high
HER2 although the cardiotoxicity restricts its clinical usage. DNA damage and ferroptosis …

Zooming in and out of ferroptosis in human disease

X Wang, Y Zhou, J Min, F Wang - Frontiers of Medicine, 2023 - Springer
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid
peroxidation. In the past decade, it has been implicated in the pathogenesis of various …