Nerve agents are organophosphorus chemical warfare agents that exert their action through
the irreversible inhibition of acetylcholinesterase, with a consequent overstimulation of …

Since the September 11, 2001, terrorist attacks in the United States, the specter of a
chemical threat against civilian populations has renewed research interest in chemical …

Butyrylcholinesterase is a promiscuous enzyme that displays complex kinetic behavior. It is
toxicologically important because it detoxifies organophosphorus poisons (OP) by making a …

Poisoning by organophosphorus compounds (OP) still is a major therapeutic problem.
Intentional OP pesticide poisoning results in up to 300.000 deaths each year and highly …

Organophosphorus agents (OP s) irreversibly inhibit acetylcholinesterase (AC hE) causing a
major cholinergic syndrome. The medical counter‐measures of OP poisoning have not …

Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many
failures in living organism and ultimately in death. Organophosphorus compounds …

Obviously, delivery of the medications to the brain is more difficult than other tissues due to
the existence of a strong obstacle, which is called blood-brain barrier (BBB). Because of the …

Alzheimer's disease (AD) is characterized by amyloid β (Aβ) peptide aggregation and
cholinergic neurodegeneration. Therefore, in this paper, we examined silibinin, a flavonoid …

After more than 70 years of considerable efforts, research on medical defense against nerve
agents has come to a standstill. Major progress in medical countermeasures was achieved …

A new series of 3‐hydroxy‐2‐pyridine aldoxime compounds have been designed,
synthesised and tested in vitro, in silico, and ex vivo as reactivators of human …