Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-
linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma …

The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …

Fibronectin structure and composition regulate contextual cell signaling. Recent advances
have been made in understanding fibronectin and its role in tissue organization and repair …

Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …