The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …

The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …

One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …

The blood-brain barrier (BBB) regulates molecular trafficking, protects against pathogens,
and prevents efficient drug delivery to the brain. Models to date failed to reproduce the …

The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …

Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …

The blood-brain barrier (BBB) tightly regulates the entry of solutes from blood into the brain
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …

Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable
modeling of human physiology and disease. The technology has emerged from converging …

The blood–brain barrier (BBB) is one of the most selective endothelial barriers. An
understanding of its cellular, morphological, and biological properties in health and disease …

The development of pharmaceutical analytical methods represents one of the most
significant aspects of drug development. Recent advances in microfabrication and …