Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma

W Luo, J Hu, W Xu, J Dong - Frontiers in Immunology, 2022 - frontiersin.org
Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …

[HTML][HTML] Tissue resident memory T cells in the respiratory tract

MZM Zheng, LM Wakim - Mucosal immunology, 2022 - Elsevier
Owing to their capacity to rapidly spread across the population, airborne pathogens
represent a significant risk to global health. Indeed, several of the past major global …

[HTML][HTML] Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

B Killingley, AJ Mann, M Kalinova, A Boyers… - Nature Medicine, 2022 - nature.com
Since its emergence in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) has caused hundreds of millions of cases and continues to circulate globally. To establish …

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization

D Lapuente, J Fuchs, J Willar, A Vieira Antão… - Nature …, 2021 - nature.com
Several effective SARS-CoV-2 vaccines are currently in use, but effective boosters are
needed to maintain or increase immunity due to waning responses and the emergence of …

Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory

KM Wragg, WS Lee, M Koutsakos, HX Tan… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination
elicit CD4+ T cell responses to the spike protein, including circulating follicular helper T …

Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2

MO Diniz, E Mitsi, L Swadling, J Rylance… - Nature …, 2022 - nature.com
T cells can contribute to clearance of respiratory viruses that cause acute-resolving
infections such as SARS-CoV-2, helping to provide long-lived protection against disease …

T cell immunity to SARS-CoV-2 following natural infection and vaccination

AT DiPiazza, BS Graham, TJ Ruckwardt - Biochemical and biophysical …, 2021 - Elsevier
SARS-CoV-2 first emerged in the human population in late 2019 in Wuhan, China, and in a
matter of months, spread across the globe resulting in the Coronavirus Disease 19 (COVID …

B-cell and antibody responses to SARS-CoV-2: infection, vaccination, and hybrid immunity

D Lapuente, TH Winkler, M Tenbusch - Cellular & Molecular …, 2024 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
prompted scientific, medical, and biotech communities to investigate infection-and vaccine …

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

F Liew, C Efstathiou, S Fontanella, M Richardson… - Nature …, 2024 - nature.com
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged
symptoms termed long coronavirus disease (COVID), yet disease phenotypes and …

Controlled human infection models to accelerate vaccine development

RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …