[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Sensory processing deficits and related cortical pathological changes in Alzheimer's disease

NK Zhang, SK Zhang, LI Zhang, HW Tao… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily affecting
cognitive functions. However, sensory deficits in AD start to draw attention due to their high …

Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status

H Shi, N Mirzaei, Y Koronyo, MR Davis… - Acta …, 2024 - Springer
This study investigates various pathological tau isoforms in the retina of individuals with
early and advanced Alzheimer's disease (AD), exploring their connection with disease …

Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer's disease

Q Cao, S Yang, X Wang, H Sun, W Chen… - Journal of Experimental …, 2024 - rupress.org
Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer’s disease |
Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …

Redefining our vision: an updated guide to the ocular immune system

M Wu, EL Fletcher, HR Chinnery, LE Downie… - Nature Reviews …, 2024 - nature.com
Balanced immune responses in the eyes are crucial to preserve vision. The ocular immune
system has long been considered distinct, owing to the so-called 'immune privilege'of its …

Early detection of dementia through retinal imaging and trustworthy AI

J Hao, WR Kwapong, T Shen, H Fu, Y Xu, Q Lu… - npj Digital …, 2024 - nature.com
Alzheimer's disease (AD) is a global healthcare challenge lacking a simple and affordable
detection method. We propose a novel deep learning framework, Eye-AD, to detect Early …

Eye-brain connections revealed by multimodal retinal and brain imaging genetics

B Zhao, Y Li, Z Fan, Z Wu, J Shu, X Yang… - Nature …, 2024 - nature.com
The retina, an anatomical extension of the brain, forms physiological connections with the
visual cortex of the brain. Although retinal structures offer a unique opportunity to assess …

Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models

G Son, TC Neylan, LT Grinberg - Molecular Neurodegeneration, 2024 - Springer
Tauopathies, a group of neurodegenerative diseases that includes Alzheimer's disease,
commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The …

Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions

J Alber, F Bouwman, J den Haan… - Alzheimer's & …, 2024 - Wiley Online Library
There is emerging evidence that amyloid beta protein (Aβ) and tau‐related lesions in the
retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)‐tau …

Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial

OM Dumitrascu, J Doustar, DT Fuchs… - Acta Neuropathologica …, 2024 - Springer
The relationship between amyloidosis and vasculature in cognitive impairment and
Alzheimer's disease (AD) pathogenesis is increasingly acknowledged. We conducted a …