Simple Summary The number of children and adults with cancer that are completely cured is
still increasing thanks to effective anti-cancer therapy, but they may be confronted with the …

Childhood, adolescent, and young adult (CAYA) cancer survivors treated with platinum-
based drugs, head or brain radiotherapy, or both have an increased risk of ototoxicity …

Background Cisplatin is used to treat a wide range of childhood cancers and cisplatin-
induced hearing loss (CIHL) is a common and debilitating toxicity. We aimed to address …

Cisplatin-induced ototoxicity results in significant, permanent hearing loss in pediatric and
adult cancer survivors. Elucidating the mechanisms underlying cisplatin-induced hearing …

Estrogen is the major female hormone involved in reproductive functions, but it also exerts a
variety of additional roles in non-reproductive organs. In this review, we highlight the …

Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular
cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has …

Ototoxicity is a common side effect of platinum treatment and manifests as irreversible, high-
frequency sensorineural hearing loss. Genetic association studies have suggested a role for …

Background Irreversible sensorineural hearing loss is a common side effect of platinum
treatment with the potential to significantly impair the neurocognitive, social and educational …

Cisplatin is a highly effective chemotherapeutic. Unfortunately, its use is limited by cisplatin‐
induced ototoxicity (CIO). Substantial research has been performed to uncover the genetic …

Background Ototoxicity has been reported after administration of aminoglycosides and
glycopeptides. Objectives To identify available evidence for the occurrence and …