Human RecQ helicases in DNA repair, recombination, and replication
DL Croteau, V Popuri, PL Opresko… - Annual review of …, 2014 - annualreviews.org
RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …
Regulation of homologous recombination in eukaryotes
WD Heyer, KT Ehmsen, J Liu - Annual review of genetics, 2010 - annualreviews.org
Homologous recombination (HR) is required for accurate chromosome segregation during
the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA …
the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA …
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
Topoisomerase I (TOP1) inhibitors are an important class of anticancer drugs. The
cytotoxicity of TOP1 inhibitors can be modulated by replication fork reversal through a …
cytotoxicity of TOP1 inhibitors can be modulated by replication fork reversal through a …
DNA helicases involved in DNA repair and their roles in cancer
RM Brosh Jr - Nature Reviews Cancer, 2013 - nature.com
Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …
Their prominence is marked by various cancers and genetic disorders that are linked to …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
Germline RECQL mutations are associated with breast cancer susceptibility
Several moderate-and high-risk breast cancer susceptibility genes have been discovered,
but more are likely to exist. To discover new breast cancer susceptibility genes, we used 2 …
but more are likely to exist. To discover new breast cancer susceptibility genes, we used 2 …
Ionizing radiation-induced oxidative stress alters miRNA expression
Background MicroRNAs (miRNAs) are small, highly conserved, non-coding RNA that alter
protein expression and regulate multiple intracellular processes, including those involved in …
protein expression and regulate multiple intracellular processes, including those involved in …
Human RecQ helicases in DNA double-strand break repair
RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …
animals. These helicases play important roles in multiple cellular functions, including DNA …
RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1
Despite being the first homolog of the bacterial RecQ helicase to be identified in humans,
the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of …
the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of …
Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors
MT Tomicic, B Kaina - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2013 - Elsevier
Topoisomerase I (TOP1) inhibitors applied in cancer therapy such as topotecan and
irinotecan are derivatives of the natural alkaloid camptothecin (CPT). The mechanism of …
irinotecan are derivatives of the natural alkaloid camptothecin (CPT). The mechanism of …