Introduction The last two decades have witnessed a rapid increase in the knowledge about
the role of the orexin system, particularly in the regulation of wakefulness and arousal. Dual …

Orexin is a neurotransmitter produced by a small group of hypothalamic neurons. Besides its
well-known role in the regulation of the sleep-wake cycle, the orexin system was shown to …

Since its description in the 19th century, narcolepsy type 1 (NT1) has been considered as a
model sleep disorder, and after the discovery of rapid eye movement (REM) sleep onset in …

In this scoping review of the literature, we identified the types and the parameters of
objective measurements to assess sleep patterns among night-shift workers. We conducted …

This article reviews the history of insomnia pharmacotherapy, documenting the evolution
that has occurred over time in the increasing availability of medications with novel …

Comments on an article by Y. Takano et al.(see record 2024-17731-001). Takano and
colleagues consider the effectiveness of first line insomnia treatment, cognitive behavioral …

Background Sleep disturbance remains common in people with Restless Legs Syndrome
(RLS), even after RLS symptoms are sufficiently controlled with medication. We conducted a …

The effects of orexinergic peptides are diverse and are mediated by orexin-1 and orexin-2
receptors. Antagonists that target both receptors have been shown to promote sleep …

The circadian wake drive is a mathematic representation of the observed increased
propensity to stay awake late in the day, peaking in the hours just before anticipated bed …

Individuals who work night shifts commonly experience difficulties with both sleep and
alertness at desired times. Additionally, shift work is increasingly recognized as a risk factor …