Allergic asthma is a frequent asthma phenotype. Both IgE and type 2 cytokines are
increased, with some degree of overlap with other phenotypes. Systematic reviews …

Background: Μonoclonal antibodies have been proposed as a novel therapy in patients
suffering from chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this …

Background Assessment of clinical outcomes in the real-world corroborates findings from
randomized controlled trials (RCTs). Objective This meta-analysis evaluated real-world data …

Background Recently developed asthma biological therapies have been shown to provide
relief for severe asthma patients not controlled by inhaled treatment. Given the relatively …

Background Availability of clinically effective and cost-effective treatments for severe asthma
would be beneficial to patients and national healthcare systems. The aim of this study was to …

Background Chronic rhinosinusitis (CRS) refractory to medical and surgical treatment is
challenging. It impacts patients' quality of life significantly. The pathophysiology of CRS has …

Objective: Estimate the economic impact of severe asthma from the Spanish social
perspective through the estimation of the associated annual direct and indirect costs …

Allergy is the host immune response towards harmless substances, called allergens.
Allergic diseases comprise allergic asthma, allergic rhinitis, allergic conjunctivitis, atopic …

From its availability for clinical use nearly two decades ago for severe asthma, omalizumab
has gained strong evidence of efficacy and safety in the treatment of severe asthma not …

Objective: To provide new insight into how chronic rhinosinusitis (CRS) is conceptualized
and treated with a focus on immunomodulator therapy. Data sources: Pubmed, Medline, and …