Update on NAFLD genetics: from new variants to the clinic

E Trépo, L Valenti - Journal of hepatology, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …

Genetics and epigenetics of NAFLD and NASH: Clinical impact

M Eslam, L Valenti, S Romeo - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …

Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women

A Cherubini, M Ostadreza, O Jamialahmadi, S Pelusi… - Nature Medicine, 2023 - nature.com
Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of liver
disease and the prevalence is rising, especially in women. Although during reproductive …

Mechanisms of liver fibrosis and its role in liver cancer

D Dhar, J Baglieri, T Kisseleva… - … Biology and Medicine, 2020 - journals.sagepub.com
Hepatic fibrogenesis is a pathophysiological outcome of chronic liver injury hallmarked by
excessive accumulation of extracellular matrix proteins. Fibrosis is a dynamic process that …

NAFLD in children: new genes, new diagnostic modalities and new drugs

V Nobili, A Alisi, L Valenti, L Miele… - Nature reviews …, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) has rapidly become the most common form of
chronic liver disease in children and adolescents. Over the past 5 years, developments have …

Mechanisms of non-alcoholic fatty liver disease in the metabolic syndrome. A narrative review

L Rinaldi, PC Pafundi, R Galiero, A Caturano… - Antioxidants, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are two different
entities sharing common clinical and physio-pathological features, with insulin resistance …

[HTML][HTML] Macrophage MerTK promotes liver fibrosis in nonalcoholic steatohepatitis

B Cai, P Dongiovanni, KE Corey, X Wang… - Cell metabolism, 2020 - cell.com
Nonalcoholic steatohepatitis (NASH) is emerging as a leading cause of chronic liver
disease. However, therapeutic options are limited by incomplete understanding of the …

Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management

T Marjot, A Moolla, JF Cobbold, L Hodson… - Endocrine …, 2020 - academic.oup.com
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disease, extending from simple
steatosis to inflammation and fibrosis with a significant risk for the development of cirrhosis. It …

[HTML][HTML] Genetic and epigenetic factors determining NAFLD risk

W Jonas, A Schürmann - Molecular metabolism, 2021 - Elsevier
Background Hepatic steatosis is a common chronic liver disease that can progress into more
severe stages of NAFLD or promote the development of life-threatening secondary diseases …

Metabolic hallmarks of hepatic stellate cells in liver fibrosis

O Khomich, AV Ivanov, B Bartosch - Cells, 2019 - mdpi.com
Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …