Monro-Kellie 2.0: The dynamic vascular and venous pathophysiological components of intracranial pressure

MH Wilson - Journal of Cerebral Blood Flow & Metabolism, 2016 - journals.sagepub.com
For 200 years, the 'closed box'analogy of intracranial pressure (ICP) has underpinned
neurosurgery and neuro-critical care. Cushing conceptualised the Monro-Kellie doctrine …

Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis

CB Beggs - BMC medicine, 2013 - Springer
Venous abnormalities contribute to the pathophysiology of several neurological conditions.
This paper reviews the literature regarding venous abnormalities in multiple sclerosis (MS) …

Brain venous haemodynamics, neurological diseases and mathematical modelling. A review

EF Toro - Applied Mathematics and Computation, 2016 - Elsevier
Abstract Behind Medicine (M) is Physiology (P), behind Physiology is Physics (P) and
behind Physics is always Mathematics (M), for which I expect that the symmetry of the …

[HTML][HTML] “People power” or “pester power”? YouTube as a forum for the generation of evidence and patient advocacy

F Mazanderani, B O'Neill, J Powell - Patient education and counseling, 2013 - Elsevier
Objective Venoplasty has been proposed, alongside the theory of chronic cerebrospinal
venous insufficiency (CCSVI), as a treatment for multiple sclerosis (MS). Despite concerns …

Potential involvement of the extracranial venous system in central nervous system disorders and aging

R Zivadinov, CP Chung - BMC medicine, 2013 - Springer
Background The role of the extracranial venous system in the pathology of central nervous
system (CNS) disorders and aging is largely unknown. It is acknowledged that the …

X-ray phase contrast tomography reveals early vascular alterations and neuronal loss in a multiple sclerosis model

A Cedola, A Bravin, I Bukreeva, M Fratini… - Scientific reports, 2017 - nature.com
The degenerative effects of multiple sclerosis at the level of the vascular and neuronal
networks in the central nervous system are currently the object of intensive investigation …

Reduced white matter venous density on MRI is associated with neurodegeneration and cognitive impairment in the elderly

C Li, H Rusinek, J Chen, L Bokacheva… - Frontiers in Aging …, 2022 - frontiersin.org
High-resolution susceptibility weighted imaging (SWI) provides unique contrast to small
venous vasculature. The conspicuity of these mesoscopic veins, such as deep medullary …

Understanding jugular venous outflow disturbance

D Zhou, JY Ding, JY Ya, LQ Pan, F Yan… - CNS neuroscience & …, 2018 - Wiley Online Library
Extracranial venous abnormalities, especially jugular venous outflow disturbance, were
originally viewed as nonpathological phenomena due to a lack of realization and …

A role for spinal cord hypoxia in neurodegeneration

E Hernandez-Gerez, IN Fleming, SH Parson - Cell Death & Disease, 2019 - nature.com
The vascular system of the spinal cord is particularly complex and vulnerable. Damage to
the main vessels or alterations to the regulation of blood flow will result in a reduction or …

The “central vein sign”: is there a place for susceptibility weighted imaging in possible multiple sclerosis?

T Kau, M Taschwer, H Deutschmann, M Schönfelder… - European …, 2013 - Springer
Objectives Susceptibility weighted imaging (SWI) may have the potential to depict the
perivenous extent of white matter lesions (WMLs) in multiple sclerosis (MS). We aimed to …