Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

Adipose tissue depots can exist in close association with other organs, where they assume
diverse, often non-traditional functions. In stem cell-rich skin, bone marrow, and mammary …

Despite the growing knowledge surrounding host–microbiome interactions, we are just
beginning to understand how the gut microbiome influences—and is influenced by—host …

Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may
represent a therapeutic target to control obesity and the progression of related metabolic …

In mammalian cells, elongases and desaturases play critical roles in regulating the length
and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In …

Excess lipid accumulation in non-adipose tissues is associated with insulin resistance,
pancreatic β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the …

A key and highly regulated enzyme that is required for the biosynthesis of monounsaturated
fatty acids is stearoyl-CoA desaturase (SCD), which catalyzes the D9-cis desaturation of a …

The liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that
are bound and activated by oxysterols. These receptors serve as sterol sensors to regulate …

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disease of the
gastrointestinal tract. Although the precise etiology of IBD remains incompletely understood …

▪ Abstract Fatty acid desaturases introduce a double bond in a specific position of long-chain
fatty acids, and are conserved across kingdoms. Degree of unsaturation of fatty acids affects …