Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities

Z Ismail, B Creese, D Aarsland, HC Kales… - Nature Reviews …, 2022 - nature.com
Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

[HTML][HTML] Apathy as a treatment target in Alzheimer's disease: implications for clinical trials

ME Mortby, L Adler, L Agüera-Ortiz, DR Bateman… - The American Journal of …, 2022 - Elsevier
Apathy is one of the most prevalent, stable and persistent neuropsychiatric symptom across
the neurocognitive disorders spectrum. Recent advances in understanding of …

Alzheimer's disease drug development pipeline: 2020

J Cummings, G Lee, A Ritter… - … research & clinical …, 2020 - Wiley Online Library
Introduction Alzheimer's disease (AD) is a growing public health concern affecting millions of
patients worldwide and costing billions of dollars annually. We review the pipeline of drugs …

A 2023 update on the advancements in the treatment of agitation in Alzheimer's disease

D Lee, ED Clark, IM Antonsdottir… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Neuropsychiatric symptoms (NPS) in Alzheimer's Disease (AD) are associated
with negative outcomes for patients and their care partners. Agitation is a common and …

Neuropsychiatric symptoms in dementia

GA Marshall - CONTINUUM: Lifelong Learning in Neurology, 2024 - journals.lww.com
Neuropsychiatric Symptoms in Dementia : CONTINUUM: Lifelong Learning in Neurology
Account Register Activate Subscription Help Subscribe American Academy of Neurology …

Dementia prevention and treatment: a narrative review

DB Reuben, S Kremen, DT Maust - JAMA Internal Medicine, 2024 - jamanetwork.com
Importance Dementia affects 10% of those 65 years or older and 35% of those 90 years or
older, often with profound cognitive, behavioral, and functional consequences. As the baby …

Drug development for psychotropic, cognitive-enhancing, and disease-modifying treatments for Alzheimer's disease

J Cummings - The Journal of neuropsychiatry and clinical …, 2021 - Am Neuropsych Assoc
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited available
therapies. There is progress in developing treatments for neuropsychiatric indications in AD …

Comparative efficacy and safety of antidepressant therapy for the agitation of dementia: A systematic review and network meta-analysis

K Chen, H Li, L Yang, Y Jiang, Q Wang… - Frontiers in Aging …, 2023 - frontiersin.org
Background Dementia is a clinical syndrome commonly seen in the elderly individuals. With
the prevalence of dementia, the incidence of neuropsychiatric symptoms in dementia …

Understanding how physical exercise improves Alzheimer's disease: cholinergic and monoaminergic systems

B Zong, F Yu, X Zhang, W Zhao, P Sun… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized by
the accumulation of proteinaceous aggregates and neurofibrillary lesions composed of β …

Drug repositioning for Alzheimer's disease: finding hidden clues in old drugs

M Ihara, S Saito - Journal of Alzheimer's Disease, 2020 - content.iospress.com
Although more than 100 years have passed since Alois Alzheimer reported a case of
Alzheimer's disease (AD), a definitive answer to the causes of cognitive impairment in the …