Gating movements and ion permeation in HCN4 pacemaker channels

A Saponaro, D Bauer, MH Giese, P Swuec, A Porro… - Molecular Cell, 2021 - cell.com
The HCN1–4 channel family is responsible for the hyperpolarization-activated cation current
I f/I h that controls automaticity in cardiac and neuronal pacemaker cells. We present …

Functionalized ZnO nanorod-based selective magnesium ion sensor for intracellular measurements

MH Asif, SMU Ali, O Nur, M Willander… - Biosensors and …, 2010 - Elsevier
ZnO nanorods were grown on a silver-coated tip of a borosilicate glass capillary (0.7 μm in
tip diameter) and used as selective potentiometric sensor of intracellular free Mg2+. To …

Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel

S Wu, W Gao, C Xie, X Xu, C Vorvis, F Marni… - Journal of General …, 2012 - rupress.org
Recently, applications of the patch-clamp fluorometry (PCF) technique in studies of cyclic
nucleotide–gated (CNG) and hyperpolarization-activated, cyclic nucleotide–regulated …

Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels

S Vemana, S Pandey… - American Journal of …, 2008 - journals.physiology.org
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are activated by
membrane hyperpolarization that creates time-dependent, inward rectifying currents, gated …

Weak Cation Selectivity in HCN Channels Results From K+-Mediated Release of Na+ From Selectivity Filter Binding Sites

D Bauer, J Wissmann, A Moroni, G Thiel… - Function, 2022 - academic.oup.com
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels generate the
pacemaker current which plays an important role in the timing of various biological …

Modulation of HCN channels in lateral septum by nicotine

SA Kodirov, M Wehrmeister, LV Colom - Neuropharmacology, 2014 - Elsevier
The effects of addictive drugs most commonly occur via interactions with target receptors.
The same is true of nicotine and its multiple receptors in a variety of cell types. However …

Distinct perinatal features of the hyperpolarization-activated non-selective cation current Ih in the rat cortical plate

A Battefeld, N Rocha, K Stadler, AU Bräuer… - Neural …, 2012 - Springer
Background During neocortical development, multiple voltage-and ligand-gated ion
channels are differentially expressed in neurons thereby shaping their intrinsic electrical …

[HTML][HTML] Use dependent attenuation of rat HCN1-mediated Ih in intact HEK293 cells

L Barthel, O Reetz, U Strauss - Cellular Physiology and Biochemistry, 2016 - karger.com
Background/Aims: Cationic currents (I h) through the fast activating and relatively cAMP
insensitive subtype of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels …

Sodium selectivity of Reissner's membrane epithelial cells

M Yamazaki, KX Kim, DC Marcus - BMC physiology, 2011 - Springer
Abstract Background Sodium absorption by Reissner's membrane is thought to contribute to
the homeostasis of the volume of cochlear endolymph. It was previously shown that the …

Functional impact of the hyperpolarization‐activated current on the excitability of myelinated A‐type vagal afferent neurons in the rat

YH Zhou, LH Sun, ZH Liu, G Bu… - Clinical and …, 2010 - Wiley Online Library
The hyperpolarization‐induced, cation‐selective current Ih is widely observed in peripheral
sensory neurons of the vagal and dorsal root ganglia, but the peak magnitude and voltage …