Function of alternative splicing
O Kelemen, P Convertini, Z Zhang, Y Wen, M Shen… - Gene, 2013 - Elsevier
Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …
the functions of alternative splicing events that have been experimentally determined. The …
Mutations in G protein–coupled receptors: mechanisms, pathophysiology and potential therapeutic approaches
There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …
these membrane receptors members of the most abundant gene family in the human …
Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
K Kataoka, Y Shiraishi, Y Takeda, S Sakata… - Nature, 2016 - nature.com
Successful treatment of many patients with advanced cancer using antibodies against
programmed cell death 1 (PD-1; also known as PDCD1) and its ligand (PD-L1; also known …
programmed cell death 1 (PD-1; also known as PDCD1) and its ligand (PD-L1; also known …
Alternative 3′ UTRs modify the localization, regulatory potential, stability, and plasticity of mRNAs in neuronal compartments
Neurons localize mRNAs near synapses where their translation can be regulated by
synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …
synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …
SQANTI3: curation of long-read transcriptomes for accurate identification of known and novel isoforms
FJ Pardo-Palacios, A Arzalluz-Luque, L Kondratova… - Nature …, 2024 - nature.com
SQANTI3 is a tool designed for the quality control, curation and annotation of long-read
transcript models obtained with third-generation sequencing technologies. Leveraging its …
transcript models obtained with third-generation sequencing technologies. Leveraging its …
RBPmap: a web server for mapping binding sites of RNA-binding proteins
Regulation of gene expression is executed in many cases by RNA-binding proteins (RBPs)
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …
DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats
Several mechanisms of action have been proposed for DNA methyltransferase and histone
deacetylase inhibitors (DNMTi and HDACi), primarily based on candidate-gene approaches …
deacetylase inhibitors (DNMTi and HDACi), primarily based on candidate-gene approaches …
Hookworm secreted extracellular vesicles interact with host cells and prevent inducible colitis in mice
RM Eichenberger, S Ryan, L Jones, G Buitrago… - Frontiers in …, 2018 - frontiersin.org
Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal
harm to their hosts, allowing them to establish chronic infections. This is mediated by …
harm to their hosts, allowing them to establish chronic infections. This is mediated by …
TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like …
C Colombrita, E Onesto, F Megiorni, A Pizzuti… - Journal of Biological …, 2012 - ASBMB
The RNA-binding proteins TDP-43 and FUS form abnormal cytoplasmic aggregates in
affected tissues of patients with amyotrophic lateral sclerosis and frontotemporal lobar …
affected tissues of patients with amyotrophic lateral sclerosis and frontotemporal lobar …
Programmed translational readthrough generates antiangiogenic VEGF-Ax
SM Eswarappa, AA Potdar, WJ Koch, Y Fan, K Vasu… - Cell, 2014 - cell.com
Translational readthrough, observed primarily in less complex organisms from viruses to
Drosophila, expands the proteome by translating select transcripts beyond the canonical …
Drosophila, expands the proteome by translating select transcripts beyond the canonical …