The binding of programmed death-1 (PD-1) on the surface of T cells and PD-1 ligand 1 (PD-
L1) on tumor cells can prevent the immune-killing effect of T cells on tumor cells and …

Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Small molecules that directly target MYC and are also well tolerated in vivo will provide
invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a …

Immune system can recognize self vs transformed self. That is why cancer immunotherapy
achieves notable benefits in a wide variety of cancers. Recently, several papers reported …

Tumor immune escape is an important strategy of tumor survival. There are many
mechanisms of tumor immune escape, including immunosuppression, which has become a …

The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis,
with various components being involved in tumor suppression and tumor growth. A …

Ovarian cancer is one of the leading causes of death in patients with gynecological
malignancy. Despite optimal cytoreductive surgery and platinum-based chemotherapy …

Background As the most abundant epigenetic modification on mRNAs and long non‐coding
RNAs, N6‐methyladenosine (m6A) modification extensively exists in mammalian cells …

Recent breakthrough results from immune checkpoint inhibitors (ICI) have paved the way to
a new era of cancer immunotherapy. In particular, inhibition of programmed death-1 (PD …