Large artery stiffness, as measured by pulse wave velocity, is correlated with high blood
pressure and may be a causative factor in essential hypertension. The extracellular matrix …

Tortuous arteries and veins are commonly observed in humans and animals. While mild
tortuosity is asymptomatic, severe tortuosity can lead to ischemic attack in distal organs …

The stiffness and structural integrity of the arterial wall depends primarily on the organization
of the extracellular matrix and the cells that fashion and maintain this matrix. Fundamental to …

The presence of various uncertainty sources in metal-based additive manufacturing (AM)
process prevents producing AM products with consistently high quality. Using electron beam …

The development of vascular grafts has focused on finding a biomaterial that is non-
thrombogenic, minimizes intimal hyperplasia, matches the mechanical properties of native …

Aims Elastin is the primary component of elastic fibres in arteries, which contribute
significantly to the structural integrity of the wall. Fibrillin-1 is a microfibrillar glycoprotein that …

Thoracic aortic aneurysms are life-threatening lesions that afflict young and old individuals
alike. They frequently associate with genetic mutations and are characterized by reduced …

Central artery stiffness has emerged over the past 15 years as a clinically significant
indicator of cardiovascular function and initiator of disease. Loss of elastic fiber integrity is …

Elastin is a highly extensible structural protein network that provides near-elastic resistance
to deformation in biological tissues. In ligament, elastin is localized between and along the …

Background Mechanical homeostasis promotes proper aortic structure and function.
Pathological conditions may arise, in part, from compromised or lost homeostasis. There is …